Форум нутрициологов России

Nutrients, Vol. 13, Pages 3: Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial

Nutrients doi: 10.3390/nu13010003

Authors: Maria Björmsjö Olle Hernell Bo Lönnerdal Staffan K. Berglund

Many infant formulas are fortified with iron at 8–14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron content and adding bovine lactoferrin to infant formula affects iron status, health and development. Swedish healthy full-term formula-fed infants (n = 180) were randomized in a double-blind controlled trial. From 6 weeks to 6 months of age, 72 infants received low-iron formula (2 mg/L) fortified with bovine lactoferrin (1.0 g/L) (Lf+), 72 received low-iron formula un-fortified with lactoferrin (Lf−) and 36 received standard formula with 8 mg of iron/L and no lactoferrin fortification as controls (CF). Iron status and prevalence of iron deficiency (ID) were assessed at 4 and 6 months. All iron status indicators were unaffected by lactoferrin. At 4 and 6 months, the geometric means of ferritin for the combined low-iron groups compared to the CF-group were 67.7 vs. 88.7 and 39.5 vs. 50.9 µg/L, respectively (p = 0.054 and p = 0.056). No significant differences were found for other iron status indicators. In the low-iron group only one infant (0.7%) at 4 months and none at 6 months developed ID. Conclusion: Iron fortification of 2 mg/L is an adequate level during the first half of infancy for healthy term infants in a well-nourished population. Adding lactoferrin does not affect iron status.


Source: https://www.mdpi.com/2072-6643/13/1/3

Робот писал(а): ↑22 дек 2020, 14:05 Nutrients, Vol. 13, Pages 3: Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial

Nutrients doi: 10.3390/nu13010003

Authors: Maria Björmsjö Olle Hernell Bo Lönnerdal Staffan K. Berglund

Many infant formulas are fortified with iron at 8–14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron content and adding bovine lactoferrin to infant formula affects iron status, health and development. Swedish healthy full-term formula-fed infants (n = 180) were randomized in a double-blind controlled trial. From 6 weeks to 6 months of age, 72 infants received low-iron formula (2 mg/L) fortified with bovine lactoferrin (1.0 g/L) (Lf+), 72 received low-iron formula un-fortified with lactoferrin (Lf−) and 36 received standard formula with 8 mg of iron/L and no lactoferrin fortification as controls (CF). Iron status and prevalence of iron deficiency (ID) were assessed at 4 and 6 months. All iron status indicators were unaffected by lactoferrin. At 4 and 6 months, the geometric means of ferritin for the combined low-iron groups compared to the CF-group were 67.7 vs. 88.7 and 39.5 vs. 50.9 µg/L, respectively (p = 0.054 and p = 0.056). No significant differences were found for other iron status indicators. In the low-iron group only one infant (0.7%) at 4 months and none at 6 months developed ID. Conclusion: Iron fortification of 2 mg/L is an adequate level during the first half of infancy for healthy term infants in a well-nourished population. Adding lactoferrin does not affect iron status.


Source: https://www.mdpi.com/2072-6643/13/1/3

Робот писал(а): ↑22 дек 2020, 14:05 Nutrients, Vol. 13, Pages 3: Reducing Iron Content in Infant Formula from 8 to 2 mg/L Does Not Increase the Risk of Iron Deficiency at 4 or 6 Months of Age: A Randomized Controlled Trial

Nutrients doi: 10.3390/nu13010003

Authors: Maria Björmsjö Olle Hernell Bo Lönnerdal Staffan K. Berglund

Many infant formulas are fortified with iron at 8–14 mg/L whereas breast milk contains about 0.3 mg/L. Another major difference between breast milk and infant formula is its high concentration of lactoferrin, a bioactive iron-binding protein. The aim of the present study was to investigate how reducing the iron content and adding bovine lactoferrin to infant formula affects iron status, health and development. Swedish healthy full-term formula-fed infants (n = 180) were randomized in a double-blind controlled trial. From 6 weeks to 6 months of age, 72 infants received low-iron formula (2 mg/L) fortified with bovine lactoferrin (1.0 g/L) (Lf+), 72 received low-iron formula un-fortified with lactoferrin (Lf−) and 36 received standard formula with 8 mg of iron/L and no lactoferrin fortification as controls (CF). Iron status and prevalence of iron deficiency (ID) were assessed at 4 and 6 months. All iron status indicators were unaffected by lactoferrin. At 4 and 6 months, the geometric means of ferritin for the combined low-iron groups compared to the CF-group were 67.7 vs. 88.7 and 39.5 vs. 50.9 µg/L, respectively (p = 0.054 and p = 0.056). No significant differences were found for other iron status indicators. In the low-iron group only one infant (0.7%) at 4 months and none at 6 months developed ID. Conclusion: Iron fortification of 2 mg/L is an adequate level during the first half of infancy for healthy term infants in a well-nourished population. Adding lactoferrin does not affect iron status.


Source: https://www.mdpi.com/2072-6643/13/1/3

Питательные вещества, Vol. 13, страницы 3: Снижение содержания железа в смеси для младенцев с 8 до 2 мг / л не увеличивает риск дефицита железа в возрасте 4 или 6 месяцев: рандомизированное контролируемое исследование

Питательные вещества doi: 10.3390 / nu13010003

Авторы: Мария Бьёрмсьё Олле Эрнелл Бо Лённердал Стаффан К. Берглунд

Многие смеси для детского питания обогащены железом в концентрации 8–14 мг / л, тогда как грудное молоко содержит около 0,3 мг / л. Еще одно важное различие между грудным молоком и детской смесью - это высокая концентрация лактоферрина, биоактивного белка, связывающего железо. Целью настоящего исследования было изучить, как снижение содержания железа и добавление бычьего лактоферрина к детской смеси влияет на уровень железа, здоровье и развитие. Шведские здоровые доношенные дети, находившиеся на искусственном вскармливании (n = 180), были рандомизированы в двойное слепое контролируемое исследование. В возрасте от 6 недель до 6 месяцев 72 ребенка получали смеси с низким содержанием железа (2 мг / л), обогащенные бычьим лактоферрином (1,0 г / л) (Lf +), 72 получали смеси с низким содержанием железа, не обогащенные лактоферрином (Lf & minus; ) и 36 получали стандартную смесь с 8 мг железа / л и без обогащения лактоферрином в качестве контроля (CF). Статус железа и распространенность дефицита железа (ID) оценивали через 4 и 6 месяцев. Лактоферрин не влиял на все показатели статуса железа. Через 4 и 6 месяцев среднее геометрическое значение ферритина для комбинированных групп с низким содержанием железа по сравнению с группой CF составило 67,7 против 88,7 и 39,5 против 50,9 мкг / л, соответственно (p = 0,054 и p = 0,056). . По другим показателям статуса железа существенных различий не обнаружено. В группе с низким содержанием железа только у одного ребенка (0,7%) в 4 месяца и ни у одного в 6 месяцев не развился ИД. Заключение. Обогащение железом 2 мг / л является адекватным уровнем в первой половине младенческого возраста для здоровых доношенных детей в хорошо питающейся популяции. Добавление лактоферрина не влияет на статус железа.


Источник: https://www.mdpi.com/2072-6643/13/1/3